Given the putative nuclear localization motif in OsMS1 (Fig. 1e and Supplementary Fig. 5) and the fact that the LXXLL motif was proposed to play a role in determining nuclear localization of Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1)37,38, we asked whether the L301P mutation in the conserved LXXLL motif of OsMS1 could influence its subcellular localization. Here, NR0B1 is linked to alternating hemiplegia of childhood.