In human, biallelic variants in CCDC141 was associated with pituitary stalk interruption syndrome (a rare disorder characterized by an absent or ectopic posterior pituitary, interrupted pituitary stalk, and anterior pituitary hypoplasia)67; and in normonosmic or anosmic hypogonadotropic hypogonadism, due to neuronal migration disorders the results in a defect in the development of the GnRH and the olfactory system68–70. The gene discussed is GNRH1; the disease is pituitary stalk interruption syndrome.