Consistent with the anti-apoptotic property of the ICB-refractory tumor cells in vivo, CT26 P3 cells were refractory to apoptotic death by cognate CTLs specific to AH-1, an immunodominant H-2Ld-restricted peptide (gp70413–423) from CT26 in vitro, whereas the CT26 P0 cells remained sensitive to cognate CTLs (Supplementary Fig. 7c). The gene discussed is DDX53; the disease is neoplasm.