Consistently, relative to CT26 P0 tumors, P3 tumors exhibited non-T cell-inflamed immune phenotypes, as evidenced by decreased levels of overall CD8+ T cells, the ratio of CD8+ T cells to T regs and tumor-reactive CD8+ T cells producing granzyme B (GrB), (Supplementary Fig. 6c–e), and anti-apoptotic phenotypes (Supplementary Fig. 6f). Here, GZMB is linked to neoplasm.