The treatment of A10 cells cultured in OM with rMFG-E8 (100 ng/mL) rescued the attenuation of mRNA levels of MMP2 and PAI-1 induced by siRNA against MFG-E8 (Fig. 6e, g), but not that of MMP9 (Fig. 6f). Here, SERPINE1 is linked to ocular melanoma.