Interestingly, when analyzing the role of the Akt/mTOR signaling pathway in the tumorigenesis and stemness of cancer, we found previous studies indicating that high MELK expression can activate the mTORC1 and mTORC2/AKT signaling pathways and promote the development of endometrial cancer (EC) [5]. The gene discussed is AKT1; the disease is endometrial cancer.