In the subsequent exploration of the molecular mechanism of xCT affecting the tumorigenesis and progression of CRC, we found that the PI3K/Akt/mTOR axis may be a potential pivotal regulatory pathway, and it was further determined in our study that xCT played a crucial role in regulating the activity of Akt/mTOR signaling in CRC cells. This evidence concerns the gene AKT1 and colorectal carcinoma.