SLC7A11 and neoplasm: xCT, which is encoded by solute carrier family 7 member 11 (SLC7A11), is a cystine/glutamate antitransporter that mediates the biosynthesis of antioxidant glutathione and antioxidant defense [4], which is essential for the survival of tumor cells and participates in mediating the growth and malignant progression of tumor cells [5, 6].