We also detected decreased ischemia-induced LCN2 secretion in exosomes from astrocytes with NHE1 inhibitor HOE642 (Fig. 4) or in exosomes from Nhe1 Astro-KO stroke brains, indicating a role of NHE1 protein in the regulation of astrocytic LCN2 expression and secretion. Here, LCN2 is linked to Stroke.