AKT2 and neoplasm: Among the first to enroll was a patient with metastatic prostate cancer that previously progressed on enzalutamide therapy, and whose pre-enzalutamide tumor harbored an in-frame AKT2 L78_Q79ins(HANTFVIRCL), an allele that we assessed in vitro for biochemical activity, transformation potential, and therapeutic sensitivity (Fig. 2c–e and Supplementary Fig. 7).