Pearson coefficients were calculated using the quantitative proteome comparing the FLT3-WT/SUCLG2high group with the FLT3-WT/SUCLG2low group, and the ranked list was used for GSEA which indicated significant enrichment for NPM1mut signatures, inv16 signatures, and MLL-rearranged AML signatures (Supplementary Fig. 1e). Here, KMT2A is linked to acute myeloid leukemia.