Within 24 h a strong increase in apoptosis was seen in the FLT3-ITD+ AML cell lines MV4–11 and MOLM13 upon incubation with ETC complex I/II inhibitors, while moderate effects were seen in FLT3-wt THP1 and HL60 cells (Fig. 2a). This evidence concerns the gene FLT3 and acute myeloid leukemia.