A cox hazard proportional model for overall survival using continuous values for gene expression signatures retrieved from the PRECOG database23 and a forest plot for multivariable analysis for SDHA, SDHB, SUCLG1, and SUCLG2 in shown in Fig. 1b, indicating that they act as independent predictors of overall survival in AML patients (see also Supplementary Data 1). This evidence concerns the gene SDHB and acute myeloid leukemia.