Downregulation of SUCLG1/2 in FLT3-ITD+ AML cell lines MOLM13 and MV4–11 also resulted in significantly lower OCR levels (Fig. 3d), but not in shSUCLG1/2 transduced FLT3-wt K562 cells (Supplementary Fig. 2k). The gene discussed is FLT3; the disease is acute myeloid leukemia.