Previously, we identified that considerable metabolic heterogeneity exists between different subtypes of AML, whereby FLT3wt AMLs, with high expression of Pyruvate Dehydrogenase Kinase 1 (PDK1) displayed more glycolytic phenotypes and FLT3-ITD AMLs were more OXPHOS-driven22. The gene discussed is FLT3; the disease is acute myeloid leukemia.