By performing proteome studies in functionally defined leukemia-initiating cell populations it was shown that FLT3-ITD+ LSCs are enriched for OXPHOS signatures37 and the authors also identified both SUCLG1 and SUCLG2 to be higher expressed in the LSC sub-compartment compared to blast population and also compared to the healthy HSPC population. Here, SUCLG1 is linked to leukemia.