Finally, analysis of H3K27ac data from different classes of healthy donor B cells (naive, memory, plasma, and germinal center B cells) revealed that the set of AXIN2 CREs in circulating B cells is limited to the intra- and indel-enhancers (i.e., no implication of the left- and/or LCL/CLL right- peripheral enhancers) (Supplementary Fig. 2d), indicating that these enhancers constitute the core AXIN2-regulating enhancers. Here, AXIN2 is linked to B-cell chronic lymphocytic leukemia.