Given rs143348853’s association with CLL (Fig. 3) and the fact that the genotype effect on AXIN2 expression could be reproduced in clinically relevant lines (Supplementary Fig. 5b), we decided to use the MEC1 line together with LCLs to unravel the mechanistic basis of rs143348853-mediated AXIN2 VCM formation and expression. The gene discussed is ATR; the disease is B-cell chronic lymphocytic leukemia.