AXIN2 and B-cell chronic lymphocytic leukemia: Our analyses suggest that the variant and thus AXIN2 up-regulation could serve as a prognostic marker since it is associated with a better outlook for 10-year event-free survival of CLL patients, especially low-risk and relatively young (<65 year old) CLL patients, consistent with our in vivo data demonstrating AXIN2’s ability to reduce in vivo CLL cell proliferation in an overexpression context.