FET (FUS-Fused in Sarcoma; EWSR1-Ewings Sarcoma breakpoint region 1; TATA box binding protein Associated Factor 15) proteins have been implicated in neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Lobar Degeneration (FTLD). This evidence concerns the gene EWSR1 and amyotrophic lateral sclerosis.