CEACAM8 and nonpapillary renal cell carcinoma: Compared with stages I&II ccRCC, stages III&IV ccRCC displayed elevated expression of complement and coagulation cascades (FGA, PLG), neutrophil degranulation (CEACAM8, CD177), membrane trafficking (KIF2A, SRC), and translation (EIF4E, EEF1A1) (Supplementary Fig. 5c, Supplementary Data 4).