Compared with stages I&II ccRCC, stages III&IV ccRCC displayed elevated expression of complement and coagulation cascades (FGA, PLG), neutrophil degranulation (CEACAM8, CD177), membrane trafficking (KIF2A, SRC), and translation (EIF4E, EEF1A1) (Supplementary Fig. 5c, Supplementary Data 4). Here, PLG is linked to nonpapillary renal cell carcinoma.