Consistently, CPTAC-GP1 was significantly associated with poorer survival than CPTAC-GP2 and CPTAC-GP3 (log-rank test, p = 0.001, Supplementary Fig. 6c), in line with the survival differences among the three subtypes in the Chinese cohort (Fig. 5b), indicating the robustness of proteomic subtyping based on the Chinese ccRCC cohort. The gene discussed is GTPBP1; the disease is nonpapillary renal cell carcinoma.