Compared with stages I&II ccRCC, stages III&IV ccRCC displayed elevated expression of complement and coagulation cascades (FGA, PLG), neutrophil degranulation (CEACAM8, CD177), membrane trafficking (KIF2A, SRC), and translation (EIF4E, EEF1A1) (Supplementary Fig. 5c, Supplementary Data 4). The gene discussed is FGA; the disease is nonpapillary renal cell carcinoma.