GP2 displayed high tumor purities (Kruskal–Wallis test, p < 2.2e-16, Supplementary Fig. 7a) and increased metabolism-related pathways, including the TCA cycle and respiratory chain, amino acid metabolism, mitochondrial translation, lipid metabolism, and glycolysis/gluconeogenesis (q < 0.05, Fig. 5g). The gene discussed is GP2; the disease is neoplasm.