We found that STAT1/2 activities, particularly STAT1 activity (Spearman’s correlation, R = 0.78, p < 2.2e-16), were significantly correlated with immune scores in ccRCC (Fig. 5l, Supplementary Fig. 7f), which indicated that activated STAT1 was an essential cause of high immune infiltration in GP1 tumors. This evidence concerns the gene GTPBP1 and nonpapillary renal cell carcinoma.