For instance, circGSK3β promotes ESCC metastasis by enhancing β-catenin signaling [17]; circ_0006948 promotes ESCC progression via miR-490-3p/HMGA2 axis [31]; circNTRK2 promotes ESCC progression by upregulating NRIP1 expression via sponging miR-140-3p [32]; ciRS-7 adsorbs miR-876-5p and enhances the expression of MAGE-A to accelerate ESCC progression [38]. This evidence concerns the gene NRIP1 and esophageal squamous cell carcinoma.