The ATX–LPAaxis has been implicated in many clinical indispositions, for example,cancer,4,5 inflammation,6 fibrosis,7 autoimmune,8 and cardiovascular diseases.9 Given its well-defined role in a plethora of pathological and physiologicalmodalities, in addition to its extracellular nature, ATX has beenactively pursued over the years as an attractive target for drug discoveryin industry and academia alike.10 This evidence concerns the gene ENPP2 and cardiovascular disorder.