ENPP2 and cancer: The ATX–LPAaxis has been implicated in many clinical indispositions, for example,cancer,4,5 inflammation,6 fibrosis,7 autoimmune,8 and cardiovascular diseases.9 Given its well-defined role in a plethora of pathological and physiologicalmodalities, in addition to its extracellular nature, ATX has beenactively pursued over the years as an attractive target for drug discoveryin industry and academia alike.10