Genes that were highly expressed in the NE-expressing subset included SYN1, INSM1, and CHGA. Drilling down on a few genes highlighting NE transcriptional regulators also revealed high expression of REST and BACH2 and low expression of DLL3 and ATOH1 in the non-NE SCLC-P subtype (Fig. 5b). This evidence concerns the gene INSM1 and small cell lung carcinoma.