We proceeded to look at a metabolic gene signature42 and interestingly, SCLC-P samples showed high expression of a subset of metabolic genes in comparison to the non-SCLC-P samples (Fig. 5e) such as ABCB6, PGD, or G6PD. While a clear subset of genes was overexpressed in the MYChi SCLC-P samples, no clear set of metabolic genes was regulated in the MYCNhi or MYCLhi SCLC samples, highlighting some degree of metabolic heterogeneity in our SCLC sample set. The gene discussed is PGD; the disease is small cell lung carcinoma.