Similar to the G-R cells established in vitro, elevated levels of PIM3 protein were also observed in the R0068 X1.2 tumor lysates compared to Par X1.6 tumors (Supplementary Fig. 13b) and enhanced inhibition of tumor growth and downstream markers was observed when ipatasertib was combined with GDC-0339 in vivo (Fig. 6e and Supplementary Fig. 13c–g). Here, PIM3 is linked to neoplasm.