To investigate whether APOE alleles influence the prionoid induction and spread of tauopathy, we injected human K18-tau aggregates unilaterally into the left hippocampus of 2.5 month old PS/E2H, PS/E3H and PS/E4H mice and analyzed ptau burden after 5 months (Fig. 1). Here, APOE is linked to tauopathy.