Similarly, PHF1 antibody also showed a similar outcome with PS/E2h mice showing higher tauopathy in the contralateral hippocampus (p < 0.01) and only a trend in ipsilateral hippocampus (p = 0.077) relative to PS/E4h mice (Additional file 9: Fig. S9 g, h). Here, PHF1 is linked to tauopathy.