Given the circadian dysregulation in tumor cells [51, 52], we investigated circadian rhythms in MDA-MB-231 and MDA-MB-468 cells by monitoring real-time bioluminescence from the introduced stable expression of the Bmal1::Luciferase and Per2::Luciferase (Supplementary Fig. 2A and B, respectively). This evidence concerns the gene PER2 and neoplasm.