Specifically, NOB (10 μM) significantly impeded the growth of MDA-MB-231, BT549, and MDA-MB-468 (Fig. 1A, 31.9%, 42.2%, and 50.9% reduction compared to DMSO at 72 h, respectively) without affecting the growth of MCF10A (normal breast epithelial cells) or MCF7 (ER/PR-positive breast cancer cells). The gene discussed is ESR1; the disease is breast carcinoma.