We found that the emTFs were enriched in the list of flanking accessibility-associated TFs reported from cancer samples in [43] (6 out of the 13 emTFs: CEBPB, GATA3, FOXA1, RUNX1, RUNX3, and TP63; Fisher test p value < 3.9e−15; Fig. 1D; Additional file 4: Table S5). This evidence concerns the gene RUNX3 and cancer.