TF and cancer: Specifically, we performed expression–methylation quantitative trait loci (emQTL) analyses by computing Spearman correlation coefficients between the expression of the 231 TFs and methylation level at 376,997 CpGs located close to TFBSs in each cancer type independently (see "Materials and methods" section for details and Additional file 4: Table S2 for the number of CpGs close to TFBSs for each TF).