Figure 4B–D provides case examples of DMRs after FOXA1 KD in the promoter regions of genes that have previously been associated with breast cancer: GREB1 (growth regulation by estrogen in breast cancer 1, a regulator of hormone-dependent breast cancer growth [54]), TFF1 (trefoil factor 1, an estrogen-regulated protein [55]), and BRIP1 (BRCA1 Interacting Protein C-Terminal Helicase 1, whose mutants participate in breast cancer development [56]). The gene discussed is TFF1; the disease is breast carcinoma.