Patients with complex phenotypes combining lipodystrophy syndrome and skeletal striated muscle and/or cardiac laminopathy, most often related to other pathogenic LMNA variants, are at risk for dilated cardiomyopathy, heart failure, conduction disorders, supraventricular and ventricular rhythm disorders and sudden death [11, 12, 30]. This evidence concerns the gene LMNA and conduction system disorder.