In case of Fib4 score > 4, F2 classification at elastometry [28], cytolysis with AST or ALT > 2N, and/or signs of cirrhosis and/or portal hypertension on ultrasound, the patient will be referred to an hepatologist, if possible from a rare liver disease network, in order to evaluate the indication of a liver biopsy (afef.asso.fr) for diagnostic and prognostic purposes, according to current recommendations (HAS-Doctor's Guide to Cirrhosis). This evidence concerns the gene GPT and liver disorder.