A consistent pattern is clear across both TSC1 and TSC2 patients where the order of co-occurrences from least probable to most probable in Boolean operator terms is P(CHD ∩ KD), P(CHD ∩ NDD) and P(KD ∩ NDD) (Additional file 1: Tables S2 and S3). This evidence concerns the gene TSC1 and coronary artery disorder.