TSC2 and tuberous sclerosis: The findings from this study also corroborate with these previous studies, indicating a significant majority of TSC patients with a mutation at the TSC2 genetic locus, with a TSC1:TSC2 mutation ratio of 2.8 TSC2 patients for every TSC1 patient, or TSC1 and TSC2 mutation rates amongst the cohort at 25% and 72%, respectively.