TSC2 and neoplasm: There was no significant difference between number of tumours observed between TSC1 and TSC2 patients; therefore, we hypothesise that the number of tumours follow the same distribution, no matter the genotype (1 tumour, z = 0.268, p = 0.787; 2–3 tumours, z = –1.10, p = 0.271; 4+ tumours, z = 1.01, p = 0.313).