Furthermore, multivariate Cox regression analyses showed that LRRN4 expression (HR = 2.364, 95% CI = 1.104–5.062, p = 0.027) was independent risk factor for poor OS (Table 4) by adjusting for gender, age, location, histological type, pathologic stage, grade and adjuvant chemoradiotherapy as covariates, indicating the significance of LRRN4 expression for outcomes in CRC patients. Here, LRRN4 is linked to colorectal carcinoma.