In agreement, we show here that BRAF and dual BRAF/MEK inhibition cause in BRAF-mut melanoma cells an initial disorganization of actin cytoskeleton and the activation of SEMA6A/RhoA/YAP pathway; the resulting massive YAP nuclear translocation functionally determines rescue of actin cytoskeleton remodeling and survival. This evidence concerns the gene RHOA and melanoma.