Furthermore, Lara-Velazquez et al. reported that AACT overexpression led to an increase in cell migration, while silencing of AACT decreased cell migration in glioblastoma and increased the survival of mice, which is positively correlated with glioma grade and negatively correlated with the prognosis of patients with GBM [54, 55]. The gene discussed is SERPINA3; the disease is glioblastoma.