In our previous study, we found that the expression level of the glycoprotein AACT and its GlcNAcylation level were decreased in the serum of patients with early-stage NSCLC, and were especially significantly decreased in stage IA, but AACT and its GlcNAcylation levels were restored and presented an increasing trend in late-stage NSCLC [16]. This evidence concerns the gene SERPINA3 and non-small cell lung carcinoma.