Sun et al. screened new plasma markers to distinguish pulmonary tuberculosis from underlying infection with quantitative proteomics technology, and found that the combination of AACT, α-1-acid glycoprotein (alpha-1-acid glycoprotein 1, AGP1) and cadherin (E-cadherin, CDH1) could distinguish patients with pulmonary tuberculosis and underlying infection, with a sensitivity of 81.2% and specificity of 95.02% [26]. Here, ORM1 is linked to infection.