However, in patients with hyperinsulinemia not only is more insulin secreted, but the production of IGFBP-1 and IGFBP-2 is diminished, therefore permitting a higher concentration of active IGF-1 which can stimulate insulin receptors (IR) on endometrial tumor cells [13, 14]. The gene discussed is IGFBP1; the disease is Hyperinsulinemia.