Of note, Wang et al. recently reported that genetic ablation of Notch2 suppressed development of CC phenotypes in murine livers expressing activated forms of AKT and YAP, while deletion of Notch1 did not affect CC development induced by AKT and YAP, signifying the role of Notch2 in hepatocyte-derived CC formation in mice [50]. Here, NOTCH2 is linked to cholangiocarcinoma.