PTPRN2 and breast cancer: For example, somatic mutation in Cub and Sushi Multiple Domains 1 (CSMD1) gene is associated with an early age of presentation in CRC individuals [68]; or mutation in PTPRN2 (Receptor-type tyrosine-protein phosphatase N2) can promote metastatic and cellular migration in breast cancer cells through lipid-dependent sequestration of an actin-remodeling factor [69].