SETD1A haploinsufficiency is associated with a range of neuropsychiatric conditions including schizophrenia, epilepsy with seizures, obsessive compulsive disorder, psychotic episodes, and intellectual disability (Kummeling et al., 2021; Nagahama et al., 2020; Singh et al., 2016; Yu et al., 2019). Here, SETD1A is linked to obsessive-compulsive disorder.