Most disease‐causing variants in RYR2 are missense variants (Olubando et al., 2020; van der Werf et al., 2012) and result in an autosomal dominant form of catecholaminergic polymorphic ventricular tachycardia (CPVT1, MIM 604772). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.