Based on our data and the study from Alspach et al. (17), we next sought to determine whether the DP CD4+ Th TILs influenced the biology of CD8+ TILs, in particular CD39+CD103+ (DP) CD8+ T cells, which are highly enriched for tumor-reactive cells (8, 11, 12). This evidence concerns the gene ITGAE and neoplasm.