The CD36 null state in humans appears at expected percentages based on the frequency of the null allele and is not known to be associated with decreased life expectancy or with risk of specific diseases, although limited studies have shown dysfunction in LCFA uptake in heart and muscle and perhaps increased risk of hypertension and metabolic syndromes (Miyaoka et al., 2001; Tanaka et al., 2001; Yanai et al., 2000). This evidence concerns the gene CD36 and metabolic syndrome.