PYCARD and early-onset autosomal dominant Alzheimer disease: In a mouse model of Alzheimer's disease, intra‐cranial delivery of anti‐ASC Abs prevented the ASC speck‐induced aggregation of Aβ in the hippocampus of APP/PS1 mice injected with Aβ seeds from APP/PS1 brain lysates (Venegas et al, 2017).