TDP‐43 aggregation is the disease‐defining pathological hallmark in > 90% of patients with amyotrophic lateral sclerosis (ALS) and ~45% of patients with frontotemporal dementia (FTD) (Gao et al, 2017; Prasad et al, 2019; Tziortzouda et al, 2021). Here, TARDBP is linked to frontotemporal dementia.