The EMT is the preliminary step in cancer metastasis whose induction is governed by epigenetic modifiers, like in the case of one of the transcription factors, Snail, which recruits multiple chromatin modifiers such as PRC2, histone deacetylase (HDAC)1/2, G9a, LSD1, to the promoter of E-cadherin, thereby promoting Snail-mediated E-cadherin repression, a hallmark of EMT [18]. The gene discussed is KDM1A; the disease is cancer.