C-myc is a potent oncoprotein, overexpression of wild-type c-myc triggers cancer in model systems, and this occurs in many human cancers where it is considered a driver oncogene.15,16 Given the predominant protumor function of c-myc, it is not surprising that c-myc functions as an integrative convergence for extracellular stimuli and as a master regulator of many downstream cellular responses and pathways. This evidence concerns the gene MYC and cancer.