HIF1A and pulmonary arterial hypertension: Quercetin with antioxidant and anti-proliferative properties has been reported to improved pulmonary artery hypertension (PAH) and pulmonary arterial pressure (PAP) possibly by affecting the expression of poly [ADP-ribose] polymerase 1 (PARP1) and miR-204 and their downstream targets, Hypoxia-inducible-factor 1A (HIF1a) and nuclear factor of activated T cells 2 (NFATc2) [97].