AGT and hypertensive disorder: HTN is also regulated by epigenetic phenomena like histone modification, DNA methylation, chromatin remodelling, and especially, ncRNA-mediated targeting of various genes, e.g. G-protein-coupled receptor kinase type 4 (GRK4) phosphorylates histone deacetylase type 1 (HDAC1), promoting its nuclear export to the cytoplasm, resulting in increased Ang II receptor type 1 (AT1R) expression and greater pressure response to Ang II [64].