In this cross-sectional analysis from the CAPIRE study, we specifically assessed the prognostic value of two indicators of HDL function, i.e. SR-BI- and ABCA-1-mediated cholesterol efflux, and found that higher SR-BI-mediated cholesterol efflux capacity, similarly to higher HDL-C levels, was associated with decreased CAD, in particular in patients with multiple risk factors, whereas lower SR-BI-mediated cholesterol efflux capacity was associated with worst clinical outcomes in patients with CAD, independently of atherosclerotic plaque features. The gene discussed is SCARB1; the disease is coronary artery disorder.