GRASP55 is the Golgi‐resident protein involved in secretory pathways of multiple cargos that bypass the Golgi (Gee et al, 2011) and its deletion in mice leads to reduced CM secretion and abnormally large LD formation which systemically results in resistance to obesity and improved insulin sensitivity (Kim et al, 2020). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.