The hypothetic link between this condition and ATGL/HSL‐mediated lipolysis activity in the intestine has not been tested so far and given the analogical function of Plin‐1 and 2 as negative regulators of ATGL activity, the involvement of Plin‐2 in colorectal cancer or IBD onset or progression might be also speculated. Here, PNPLA2 is linked to colorectal cancer.