There is increasing evidence demonstrating that gastrointestinal hormones not only play a central role in regulating food intake, nutrient absorption, intestinal movement, weight control, and energy balance but also in insulin secretion, glucose homeostasis, immune system regulation, etc.1, 2With the continuous progress of people's understanding of the structure and pathophysiology of gastrointestinal hormones, gastrointestinal hormones have become a promising hot spot for the treatment of diabetes. The gene discussed is INS; the disease is diabetes mellitus.