MUC16 and ovarian carcinoma: In some of these cases, the cancers were diagnosed within a year after a negative screening test which would lead to false reassurance for patients, assuming they were missed at the previous screening test.20 Transvaginal ultrasound and CA-125 had high specificity rates based on three11 14 21 studies, one of which had no false positives or ovarian cancers, questioning the selection of patients for screening.