This aligns with recent recommendations for risk reducing salpingo-oophorectomy for MSH2 and MLH1 carriers and not for MSH6 and PMS2 carriers.3 In the Prospective Lynch Syndrome Database, ovarian cancer had a high 5 year and 10 year survival rate of 84%3 compared with 46% in the general Australian population.44 This could be due to the highly screened targeted population and younger age group included in the former, or the specific phenotype of Lynch syndrome cancers. This evidence concerns the gene MSH2 and cancer.