In some of these cases, the cancers were diagnosed within a year after a negative screening test which would lead to false reassurance for patients, assuming they were missed at the previous screening test.20 Transvaginal ultrasound and CA-125 had high specificity rates based on three11 14 21 studies, one of which had no false positives or ovarian cancers, questioning the selection of patients for screening. This evidence concerns the gene MUC16 and cancer.