STAT1 and infection: The protective role of IFN-I against CCHFV has been exemplified in animal models in which IFNAR−/− or STAT-1−/− mice (Bente et al., 2010; Zivcec et al., 2013) or STAT2−/− hamsters (Ranadheera et al., 2020) showed enhanced susceptibility to CCHFV-infection.