Moreover, p-AKT (Ser473) and p-ERK1/2(Thr202/Tyr204) were decreased in CTSS knockdown cells (Fig. 7F and Fig. S5J), and it meant that AKT/ERK1/2 signaling axis was inactivated in CTSS-depleted glioma cells. Here, CTSS is linked to central nervous system cancer.