In sum, our present work identifies three molecules, (i) the obesogenic factor ACBP, (ii) the ACBP receptor GABAAR, and (iii) the ACBP-transactivating TF PPARγ, as elements of a vicious amplification loop that likely contributes to the pathogenesis of obesity and its comorbidities. This evidence concerns the gene DBI and obesity due to melanocortin 4 receptor deficiency.