Although most mutations in Deltacron’s spike protein derive from Omicron, the impact of the recombination on viral transmissibility and the ability to escape neutralizing antibodies elicited by vaccination is unclear.24 Our results confirmed the effectiveness of the bivalent inactivated vaccine sequential immunization strategy against Omicron in vivo and in Rhesus macaques, which will rationally guide vaccination regimes against COVID-19. The gene discussed is CHMP5; the disease is COVID-19.