SHBG and endometrial cancer: Recent MR studies have suggested potential causal relationships between circulating levels of several molecular traits, including low-density lipoprotein (LDL) cholesterol, insulin, total and bioavailable testosterone, and sex hormone-binding globulin (SHBG) and endometrial cancer risk, and have confirmed a causal role of BMI in endometrial cancer risk [17, 25–31].