The effect of SHBG on overall endometrial cancer fully attenuated when bioavailable testosterone (a presumed downstream mediator of SHBG) was included in the model (OR per increase in INT nmol/L SHBG 1.08, 95% CI 0.86 to 1.36, P = 5.00 × 10−1). The gene discussed is SHBG; the disease is endometrial cancer.