Moreover, IL-6 and IL-1β transcription in mesenteric and periovarian WAT was greatly decreased in both PCOS-like and obese rats after EA treatment, similar to trends in inguinal WAT (Fig. 5C, D), indicating that the improvement of chronic inflammation in WAT played a major role in EA-affected obesity. Here, IL1B is linked to obesity due to melanocortin 4 receptor deficiency.