CD274 and neoplasm: Additionally, pre-immunotherapy treatment tumor samples of twenty-nine NSCLC patients from this group of patients were subjected to targeted DNA sequencing and PD-L1 immunochemistry staining, revealing that TPS was positively correlated with the degree of pathologic regression, TMB was not significantly correlated with pathologic regression, and that the copy number gain burden was significantly negative correlated with pathologic regression [73].