In the USA, there are six PD-1/PD-L1 inhibitors approved by the FDA to treat NSCLC; among them, pembrolizumab, nivolumab and cemiplimab are PD-1 blockers; and durvalumab, avelumab and atezolizumab are PD-L1 blockers [22]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.