For example, if an adult IDH-wildtype diffuse astrocytic tumor shows low-grade histologic features yet harbors one or more of 3 key genetic alterations (TERT promoter mutation, EGFR gene amplification and/or combined gain of entire chromosome 7 and loss of entire chromosome 10 [+ 7/-10]), it is considered glioblastoma [3]. The gene discussed is TERT; the disease is glioblastoma.