INS and diabetes mellitus: Some scholars have also studied the glucose metabolism of verapamil, which shows that verapamil can reduce blood glucose of patients with diabetes [26]; oral administration of verapamil for 12 months can promote beta cell function, reduce insulin demand and the occurrence of hypoglycemia in adult patients with T1DM [27]; compared with other calcium channel blockers, oral administration of verapamil in patients with no history of diabetes can reduce the incidence of T2DM, especially in elderly patients [28].