Previous studies have found that verapamil can improve insulin sensitivity in T2DM mice, and then significantly improve blood glucose homeostasis, inhibit the expression of thioredoxin (TXNIP), promote the growth of islet β cells, enhance insulin secretion, significantly increase the serum insulin level, thus significantly reduce blood glucose of T2DM mice [44]. This evidence concerns the gene TXNIP and type 2 diabetes mellitus.