CAPN1 and hypertensive disorder: Some studies have pointed out that the combination of tradopril and verapamil can treat hypertension in patients with type 2 diabetes [21]; verapamil can improve the structure, function and metabolism of human brain vascular endothelial cells [22, 23]; in addition, the activities of calpain-1 and matrix metalloproteinase-2 are reduced, and the cardiac remodeling induced by hypertension in rats is improved after verapamil treatment [24]; verapamil can also reduce inflammation and joint destruction in the arthritis model of 10 week-old male DBA1/J mice [25].