INS and diabetes mellitus: For the patients with moderate diabetes, verapamil might be considered as an option for treatment, because verapamil could not only tend to decrease blood glucose, but also tended to increase bone mass, microstructure, macro and nano mechanical properties of rats; considering the therapeutic effect and economic cost, the use of this drug could achieve better therapeutic effect, and there was no need to choose the drugs with higher cost, e.g. insulin.