Based on the strong correlation of B cell IFNβ with serum anti-Sm and historic positivity of LN in SLE, we correlated IFNβ in naïve B cells in the peripheral blood mononuclear cell (PBMC) with histopathological features of renal biopsy specimens obtained from the same SLE patients. This evidence concerns the gene IFNB1 and systemic lupus erythematosus.