WNT5A showed a statistically significant decrease by 58% in the Charcot group when compared to the healthy controls (median = 0.4240; p < 0.0001), and a notable decrease of gene expression by 40% when compared to T2DM patients (median = 0.7060; p = 0.0172). This evidence concerns the gene WNT5A and type 2 diabetes mellitus.